(r)-3-Cyclohexyl-2,3-dihydro-6-[(cis)-4-benzyl-2,6-dimethylpiperazin-1-yl-carbonyl]pyrrolo[1,2,3-de]-1,4-benzoxazine hydrochloride salt → (r)-3-Cyclohexyl-2,3-dihydro-6-[(cis)-2,6-dimethylpiperazin-1-ylcarbonyl]pyrrolo-[1,2,3-de]-1,4-benzoxazine hydrochloride salt

Participants

Reaction Steps

To a solution of (R)-3-cyclohexyl-2,3-dihydro-6-[(cis)-4-benzyl-2,6-dimethylpiperazin-1-ylcarbonyl]pyrrolo[1,2,3-de]-1,4-benzoxazine hydrochloride salt (200 mg, 0.42 mmol) in ethanol (5 ml) was added 10% palladium on charcoal (10 mg). The mixture was stirred under a hydrogen atmosphere for 16 h at room temperature. The mixture was filtered and the solvent removed in vacuo to afford the title compound as a white solid (100 mg, 0.26 mmol).

Provenance & Evidence