Triethylamine → tert-Butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate

HRID 500505Notes

Reaction equation

HRID 500505 reaction equation
C(N(CC)CC)C.Br[CH2:9][CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15].[CH:19]12[O:27][CH:23]([CH2:24][NH:25][CH2:26]1)[CH2:22][N:21]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]1[CH:39]=[CH:38][C:35]([C:36]#[N:37])=[CH:34][CH:33]=1)[CH2:20]2>CN(C=O)C>[C:36]([C:35]1[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:21]2[CH2:22][CH:23]3[O:27][CH:19]([CH2:26][N:25]([CH2:9][CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:24]3)[CH2:20]2)=[CH:39][CH:38]=1)#[N:37]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 4103526tert-Butyl N-(2-bromoethyl)carbamateHCID 179653304-[4-(9-Oxa-3,7-diazabicyclo[3.3.1]non-3-yl)butyl]benzonitrile

Product 1

HCID 9888837tert-Butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
54 °C

Procedure

Triethylamine (2.2 mL, 0.016 mol) and tert-butyl 2-bromoethylcarbamate (see Preparation R above, 2.83 g, 0.013 mol) were added to a solution of 4-[4-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)butyl]benzonitrile (see Preparation G above, 3.0 g, 0.011 mol) in DMF (50 mL). The mixture was stirred for 24 h at 54° C., cooled to 25° C., and concentrated in vacuo. The residue was dissolved in chloroform and washed with saturated sodium chloride. The aqueous layer was separated and extracted with chloroform (2×150 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo. The resulting material was chromatographed on silica gel, eluting first with chloroform:acetonitrile:conc. ammonium hydroxide (9:1:0.02) until the higher Rf impurities were removed. Then the eluent was switched to chloroform:methanol:conc. ammonium hydroxide (9:1:0.02). This afforded 2.76 g (61%) of the title compound.

Workup

  1. temperaturecooled to 25° C.
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue was dissolved in chloroform
  4. washwashed with saturated sodium chloride
  5. customThe aqueous layer was separated
  6. extractionextracted with chloroform (2×150 mL)
  7. dry with materialThe combined organic layers were dried (Na2SO4)
  8. concentrationconcentrated in vacuo
  9. customThe resulting material was chromatographed on silica gel
  10. washeluting first with chloroform
  11. customammonium hydroxide (9:1:0.02) until the higher Rf impurities were removed

Sources & evidence

ORD record
ord-01493e9dd558468aab7584a32b31dbc6
Source dataset
uspto-grants-2010_08
Patent number
US07772229B2

Reaction notes

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