Hydroxyamine hydrochloride → Ethyl 5-(3-chlorophenyl)isoxazole-3-carboxylate

関与物質

反応手順

A solution of the title compound of Example 3.1 (3.00 g, 11.8 mmol) and hydroxylamine hydrochloride (2.46 g, 35.4 mmol) in methanol (60 mL) was heated at 80° C. for 4 hours. After cooling, the mixture was filtered and washed with cold methanol to afford the title compound in mixture with the methyl ester analog (2.0 g, 71%, white solid).

情報源と証拠