反应详情

In a screw cap vial equipped with stir bar added the title compound of Example 6.1 (100 mg, 0.45 mmol), sodium borohydride (34 mg, 0.90 mmol) and methanol (3 mL). The resulting mixture was stirred at room temperature for 3 h. The reaction was quenched with water (30 mL) and brine (30 mL), extracted with dichloromethane (3 times 30 mL). The combined organic phase was dried (sodium sulfate), filtered and concentrated, in vacuo to isolate the title compound as a white solid (110 mg).

1. customIn a screw cap vial
2. customequipped
3. stirringThe resulting mixture was stirred at room temperature for 3 h
4. customThe reaction was quenched with water (30 mL) and brine (30 mL)
5. extractionextracted with dichloromethane (3 times 30 mL)
6. dry with materialThe combined organic phase was dried (sodium sulfate)
7. filtrationfiltered
8. concentrationconcentrated, in vacuo