HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500540Generated: October 30, 2026
Hydrazine hydrate (1:1) → 6-Oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,6-dihydropyridazine-4-carbohydrazide
https://huagongshe.com/reaction/500540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 6-Oxo-1-(2-trimethylsilanyl-ethoxymethyl)-1,6-dihydro-pyridazine-4-carboxylic acid ethyl ester | HCID 24851702 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,6-dihydropyridazine-4-carbohydrazide | HCID 24851703 | — |
Reaction Steps
The title compound from Example 19.2 (0.85 g, 2.8 mmol) was stirred in ethanol. Hydrazine hydrate (0.720 g, 14.2 mmol) was added to the solution and the reaction was stirred at 50° C. for 1 hour. The reaction was concentrated and triturated with methanol and diethyl ether to produce a precipitate which was collected by vacuum filtration as the title compound (0.56 g, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07772235B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-a7cd0a8d955c472eaf3c100b1e724384 |
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| Source note | uspto-grants-2010_08 |
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