反应详情

The title compound of example 25.1 (21.97 g, 92.97 mmol) was partially dissolved in methanol (500 mL) and OXONE® (potassium peroxomonosulfate compound, 114.3 g, 186.0 mmol) dissolved in water (500 mL) was added slowly. The reaction mixture stirred for 5 hours. The reaction was partially concentrated, poured into water and extracted with chloroform. The organic extracts were dried, filtered and concentrated to afford the title compound (22 g, 93%) as a white solid.

1. additionwas added slowly
2. concentrationThe reaction was partially concentrated
3. additionpoured into water
4. extractionextracted with chloroform
5. customThe organic extracts were dried
6. filtrationfiltered
7. concentrationconcentrated