反应详情

温度

65 °C

The title compound from example 29.1 (103 mg, 0.298 mmol), the title compound from example 7.1 (100 mg, 0.4471 mmol) and cesium carbonate (291 mg, 0.894 mmol) were combined in a screw cap vial which was purged with nitrogen. Dimethylformamide (3 mL) was added and the reaction was stirred at 65° C. overnight. The reaction mixture was then cooled to room temperature, diluted with water and extracted three times with dichloromethane. The combined organics were dried over magnesium sulfate, filtered and concentrated, then chromatographed in dichloromethane followed by ethyl acetate on silica gel to give the title compound (129.4 mg, 58%).

1. customcap
2. customwhich was purged with nitrogen
3. additionDimethylformamide (3 mL) was added
4. temperatureThe reaction mixture was then cooled to room temperature
5. additiondiluted with water
6. extractionextracted three times with dichloromethane
7. dry with materialThe combined organics were dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customchromatographed in dichloromethane