反应详情

温度

60 °C

The title compound from example 17.1 (96 mg, 0.43 mmol), the title compound from example 34.1 (100 mg, 0.36 mmol) and cesium carbonate (419 mg, 1.29 mmol) were combined with a stir bar in a screw cap vial which was purged with nitrogen. The combined reagents were stirred in DMF and heated to 60° C. overnight. The reaction mixture was then diluted with water and extracted three times with chloroform. The organic phase was dried over magnesium sulfate, filtered and concentrated then chromatographed in 0-10% methanol in ethyl acetate (pale solid, 105 mg, 68%).

1. customcap
2. customwhich was purged with nitrogen
3. additionThe reaction mixture was then diluted with water
4. extractionextracted three times with chloroform
5. dry with materialThe organic phase was dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customthen chromatographed in 0-10% methanol in ethyl acetate (pale solid, 105 mg, 68%)