O-(cyclopropylmethyl)hydroxylamine → HCID 59424205, compound

HRID 500580Notes

Reaction equation

HRID 500580 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]([F:19])=[C:17]3[C:12]([C:13]([CH3:20])=[CH:14][CH:15]=[N:16]3)=[CH:11][C:10]=2[C:21](O)=[O:22])=[C:4]([F:24])[CH:3]=1.[CH:25]1([CH2:28][O:29][NH2:30])[CH2:27][CH2:26]1>>[CH:25]1([CH2:28][O:29][NH:30][C:21]([C:10]2[CH:11]=[C:12]3[C:17](=[C:18]([F:19])[C:9]=2[NH:8][C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=2[F:24])[N:16]=[CH:15][CH:14]=[C:13]3[CH3:20])=[O:22])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 11182605O-(cyclopropylmethyl)hydroxylamineHCID 66999300HCID 66999300, compound

Product 1

HCID 59424205HCID 59424205, compound

Procedure

The title compound is prepared from 7-(4-bromo-2-fluorophenylamino)-8-fluoro-4-methyl-quinoline-6-carboxylic acid in the same manner described in step J for Example 1 using O-cyclopropylmethyl-hydroxylamine in place of O-(2-vinyloxy-ethyl)-hydroxylamine.

Sources & evidence

ORD record
ord-257bd47a1513420e831d6c8026fda4e2
Source dataset
uspto-grants-2010_08
Patent number
US07772234B2

Reaction notes

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