Potassium Carbonate → HCID 21931920, compound

Participants

Reaction Steps

A mixture of 2′,4′-dichloro-6-methyl-biphenyl-2-ol (8.75 g, 34.7 mmol), K2CO3 (25 g, 180 mmol) and CuO (17 g, 214 mmol) in 200 mL of pyridine was refluxed under nitrogen for 2 hours. Pyridine was eliminated by distillation. To the residue were added 200 mL of water and 200 mL of methylenechloride, the resulting mixture was filtered through Celite. The organic phase was washed with water, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (cyclohexane/ethyl acetate, 5/1) to give 6.27 g of beige solid.

Provenance & Evidence