反应详情

The alcohol 51 (880 mg, 2.22 mmol) was suspended in SOCl2 (10 ml) and the reaction mixture was refluxed for 1 hour, cooled and carefully poured onto ice/water. A precipitate was formed which was collected by filtration, washed with additional cold water and dried under vacuum to afford the title compound 52 (919 mg, 100% yield), which was used without additional purification. MS (m/z): 415.1(100%) (M+H), 417.1 (36%) (M+H).

1. temperaturethe reaction mixture was refluxed for 1 hour
2. temperaturecooled
3. additioncarefully poured onto ice/water
4. customA precipitate was formed which
5. filtrationwas collected by filtration
6. washwashed with additional cold water
7. customdried under vacuum