2-Fluoro-4-nitrophenol → HCID 59424608, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 100 (250.0 mg, 0.54 mmol) in Ph2O (4 ml) was added 2-fluoro-4-nitrophenol (171 mg, 1.1 mmol) and potassium carbonate (304 mg, 2.2 mmol). The reaction mixture was heated to 195° C. for 3 hrs, cooled to room temperature, diluted with DCM, filtered and concentrated. The residue was purified by column chromatography, eluents EtOAc, then MeOH/EtOAc (20-80), to afford title compound 101 (94 mg, 30% yield) as a white solid. MS (m/z): 580.3 (M+H).

Provenance & Evidence