HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → Methyl 2-(7-chlorothieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 7-Chloro-2-(1,3-thiazol-2-yl)thieno[3,2-b]pyridine | HCID 22143663 | — |
| Reactant | Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate | HCID 26343677 | — |
| Reactant | 7-Chloro-2-(tributylstannyl)thieno[3,2-b]pyridine | HCID 57516658 | — |
| Product | Methyl 2-(7-chlorothieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carboxylate | HCID 59424560 | — |
Reaction Steps
Starting from the compound 98 (scheme 19) and following the procedure described above for the synthesis of compound 10 (example 12, scheme 2) but substituting 2-bromothiazole in the step 2 for the bromide 118, title compound 119 was obtained as a white solid (580 mg, 100% yield). MS (m/z) 308.1/310.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772247B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-ae251a2e753c46758971fab19a4aac10 |
| Source note | uspto-grants-2010_08 |