HCID 86604167, compound → HCID 86604170, compound

HRID 500811Notes

Reaction equation

HRID 500811 reaction equation
[ClH:1].FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12.FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12.C([O:82][C:83]([C@@H:85]1[CH2:89][CH2:88][CH2:87][N:86]1[C:90]([C:92]1[S:100][C:99]2[C:94](=[N:95][CH:96]=[CH:97][C:98]=2[O:101][C:102]2[CH:107]=[CH:106][C:105]([NH:108][C:109]([NH:111][C:112](=[O:120])[CH2:113][C:114]3[CH:119]=[CH:118][CH:117]=[CH:116][CH:115]=3)=[S:110])=[CH:104][C:103]=2[F:121])[CH:93]=1)=[O:91])=[O:84])(C)(C)C>>[ClH:1].[F:121][C:103]1[CH:104]=[C:105]([NH:108][C:109]([NH:111][C:112](=[O:120])[CH2:113][C:114]2[CH:115]=[CH:116][CH:117]=[CH:118][CH:119]=2)=[S:110])[CH:106]=[CH:107][C:102]=1[O:101][C:98]1[CH:97]=[CH:96][N:95]=[C:94]2[CH:93]=[C:92]([C:90]([N:86]3[CH2:87][CH2:88][CH2:89][C@H:85]3[C:83]([OH:84])=[O:82])=[O:91])[S:100][C:99]=12

Participants

4

Reactant 3

HCID 86604167HCID 86604167, compoundHCID 86604168HCID 86604168, compoundHCID 86604172HCID 86604172, compound

Product 1

HCID 86604170HCID 86604170, compound

Procedure

Following the procedure described above for the synthesis of compound 136a (Example 93) but substituting compound 135d (example 92, table 11) for the compound 135a (Example 89, Table 11), title compound 136c was obtained. Characterization of this material is provided in Table 12.

Sources & evidence

ORD record
ord-d288b671e9d44b92ad9f7c3bd36b9baf
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

Loading…