HCID 59424495, compound → HCID 86604173, compound

HRID 500814Notes

Reaction equation

HRID 500814 reaction equation
Cl.FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12.[Cl:40][C:41]1[CH:42]=[C:43]([NH:65][C:66]([NH:68][C:69](=[O:77])[CH2:70][C:71]2[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=2)=[S:67])[CH:44]=[C:45]([Cl:64])[C:46]=1[O:47][C:48]1[CH:53]=[CH:52][N:51]=[C:50]2[CH:54]=[C:55]([C:57]([N:59]3[CH2:63][CH2:62][CH2:61][CH2:60]3)=[O:58])[S:56][C:49]=12>>[Cl-:40].[Cl:40][C:41]1[CH:42]=[C:43]([NH:65][C:66]([NH:68][C:69](=[O:77])[CH2:70][C:71]2[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=2)=[S:67])[CH:44]=[C:45]([Cl:64])[C:46]=1[O:47][C:48]1[CH:53]=[CH:52][NH+:51]=[C:50]2[CH:54]=[C:55]([C:57]([N:59]3[CH2:60][CH2:61][CH2:62][CH2:63]3)=[O:58])[S:56][C:49]=12

Participants

3

Reactant 2

HCID 59424495HCID 59424495, compoundHCID 86604167HCID 86604167, compound

Product 1

HCID 86604173HCID 86604173, compoundYield 42%

Procedure

Following the procedure described above for the synthesis of compound 136a (Table 12, Example 93) but replacing compound 135d with compound 142, title compound 143 was obtained in 42% yield. Characterization of 143 is provided in the Table 13.

Sources & evidence

ORD record
ord-36c7360c60954b47b1ee6ef390ed6df3
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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