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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500821Generated: October 30, 2026

(3-hydroxyphenyl)boronic Acid → 3-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenol

https://huagongshe.com/reaction/500821

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-hydroxyphenyl)boronic AcidHCID 2734359—
Reactant4-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenolHCID 136059648—
Product3-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenolHCID 5942445366%

Reaction Steps

Starting from the nitrobromo compound 42, following the procedure described above for the synthesis of compound 153 (scheme 28, example 109) but substituting 4-hydroxyphenylboronic acid for 3-hydroxyphenylboronic acid, title compound 160 was obtained in 66% yield as a gray solid. LRMS (M+1) 383.1 (100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07772247B2
Source datasetuspto-grants-2010_08
ORD IDord-d1f28c1e8b3342e284829271ba6d079e
Source noteuspto-grants-2010_08