7-Chlorothieno[3,2-b]pyridine → 7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

HRID 500824Notes

Reaction equation

HRID 500824 reaction equation
ClC1C=CN=C2C=CSC=12.[F:11][C:12]1[CH:32]=[C:31]([N+:33]([O-:35])=[O:34])[CH:30]=[CH:29][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]2[CH:21]=[C:22](C(N(C)C)=O)[S:23][C:16]=12>>[F:11][C:12]1[CH:32]=[C:31]([N+:33]([O-:35])=[O:34])[CH:30]=[CH:29][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]2[CH:21]=[CH:22][S:23][C:16]=12

Participants

3

Reactant 2

HCID 112752517-Chlorothieno[3,2-b]pyridineHCID 594244757-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide

Product 1

HCID 594246827-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridineYield 45%

Procedure

Starting from the chloride 2 (scheme 1) and following the procedure described above for the synthesis of compound 6 (scheme 1, example 1), title compound 168 was obtained in 45% yield. LRMS (M+1) 290.3 (100%).

Sources & evidence

ORD record
ord-6b568883200446e1862aab378efc6128
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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