4-Chlorothieno[3,2-d]pyrimidine → 4-Chlorothieno[3,2-d]pyrimidine-6-carbaldehyde

HRID 500835Notes

Reaction equation

HRID 500835 reaction equation
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.ClC1C=CN=C2C=C([CH:21]=[O:22])SC=12>>[Cl:1][C:2]1[C:3]2[S:10][C:9]([CH:21]=[O:22])=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 27358214-Chlorothieno[3,2-d]pyrimidineHCID 509888497-Chlorothieno[3,2-b]pyridine-2-carbaldehyde

Product 1

HCID 594244234-Chlorothieno[3,2-d]pyrimidine-6-carbaldehydeYield 84%

Procedure

Starting from 4-chloro-thieno[3,2-d]pyrimidine (20, scheme 4) and following procedure described above for the synthesis of aldehyde 14 (scheme 3, step 1, example 20), title compound 186 was obtained in 84% yield. LRMS (M+1) 199.0 (100%).

Sources & evidence

ORD record
ord-5448f255f280475dbe1bad17f8d6c358
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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