2-(2-Thienyl)ethanoyl isothiocyanate → N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-(thiophen-2-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(2-Thienyl)ethanoyl isothiocyanate	HCID 21890386	—
Reactant	N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide	HCID 24901699	—
Reactant	1-(4-(7-Benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea	HCID 86609660	—
Product	N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-(thiophen-2-yl)acetamide	HCID 86604181	9%

Reaction Steps

Starting from the amine 169 (scheme 33), following the procedures described above for the synthesis of compound 170a (example 133) but replacing 2-phenylacetyl isothiocyanate with 2-(thiophen-2-yl)acetyl isothiocyanate, title compound 192b was obtained in 9% yield. Characterization of 192b is provided in table 18.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07772247B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-f5ce791137fe496fb67c796429e55fd0
Source note	uspto-grants-2010_08