(7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone → (7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	(7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone	HCID 11173165	—
Reactant	7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide	HCID 59424475	—
Product	(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone	HCID 59424552	93%

Reaction Steps

Starting from (7-chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone (139, scheme 26) and following the procedure described above for the synthesis of compound 6 (scheme 1, example 1), title compound 193 was obtained in (93% yield). LRMS (M+1) 387.4 (100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07772247B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-969e09178ae74772b882fc08d8db731e
Source note	uspto-grants-2010_08