Bromine → HCID 178515290, compound

HRID 500897Notes

Reaction equation

HRID 500897 reaction equation
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2[OH:10])[CH:3]=[CH:2]1.[Br:11]Br>C(O)(=O)C>[Br:11][C:7]1[C:8]([OH:10])=[C:9]2[S:1][CH:2]=[CH:3][C:4]2=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 5074765Thieno[3,2-b]pyridin-7-ol

Product 1

HCID 178515290HCID 178515290, compoundYield 115.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of thieno[3,2-b]pyridin-7-ol (1, 2.55 g, 16.87 mmol) in acetic acid (50 mL) was added bromine(1.7 mL, 32.72 mmol). The mixture was heated at 110° C. for 1 h, cooled and the resultant precipitate was separated by filtration, to afford the title compound 270 (4.47 g, crude) as a dark brown powder, which was used in next step without further purification. M/S (m/z): 231.9(M+H) (found).

Workup

  1. temperaturecooled
  2. customthe resultant precipitate was separated by filtration

Sources & evidence

ORD record
ord-4da2aa6a3daf4db7a37eef5c82f8f2ca
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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