反应详情

温度

130 °C

3-Bromo-5-methyl-2-pyrazineamine (3.5 g, 18.6 mmol) and methyl 2-chloro-3-oxopentanoate (6.7 mL, 48.6 mmol) were mixed, and the mixture was heated under stirring at 130° C. for 1 hour. After being allowed to cool, the unnecessary materials were filtered off and washed with ethyl acetate, and then the filtrates were combined and evaporated. The resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to give the title compound (0.32 g) as pale yellow crystals.

1. temperaturethe mixture was heated
2. temperatureto cool
3. filtrationthe unnecessary materials were filtered off
4. washwashed with ethyl acetate
5. customevaporated
6. customThe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)