Methyl 2-chloro-3-oxopentanoate → HCID 22024701, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-chloro-3-oxopentanoate (5 mL) was added to 4-(2,4-dimethylphenyl)-3-pyridazineamine (640 mg, 3.2 mmol), and the mixture was heated at 155° C. for 30 minutes. Water was added to the resulting reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with a 5N aqueous sodium hydroxide solution and brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (ethyl acetate:N-hexane=1:3) to give the title compound (373 mg, 37%) as a brown oil.

Provenance & Evidence