2-Amino-1-butanol → HCID 22024413, compound

HRID 501005Notes

Reaction equation

HRID 501005 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH2:9][CH:10]([CH2:13][CH3:14])[CH2:11][OH:12]>O1CCOCC1>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:9][CH:10]([CH2:13][CH3:14])[CH2:11][OH:12])[CH:7]=1

Participants

4

Reactant 2

HCID 221292-Amino-1-butanolHCID 709434,6-Dichloropyrimidine

Product 1

HCID 22024413HCID 22024413, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4,6-Dichloropyrimidine (5.0 g) and 2-amino-1-butanol (6.5 mL) were heated under reflux in 1,4-dioxane (26 mL) for 1 hour. The reaction mixture was evaporated, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10) to give the title compound (5.6 g) as a pale orange oil.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10)

Sources & evidence

ORD record
ord-60c70e24425b47b49709050173684837
Source dataset
uspto-grants-2010_08
Patent number
US07772249B2

Reaction notes

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