Potassium Carbonate → HCID 25014931, compound

Participants

Reaction Steps

2-Benzofuranboronic acid (3.1 mmol), 5-bromopyridine-2-carboxamide (3.7 mmol), 2M K2CO3 (aq., 6 mL) and Pd(dppf)Cl2 (0.31 mmol) were mixed and stirred at 80° C. in DMF for 2 h. The reaction mixture was filtered and washed with H2O and EtOAc. DMSO was added to the solid remains and filtered. The filtrate was collected and purified by reverse phase HPLC to afford the title compound as a white solid (2.5 mg). 1H NMR δ ppm 9.18 (d, 1 H) 8.46 (dd, 1 H) 8.13-8.19 (m, 2 H) 7.68-7.78 (m, 4 H) 7.43-7.30 (m, 2 H); MS m/z 239 (M+H).

Provenance & Evidence