反应详情

10% Palladium on carbon (10 mg) was added to a solution of benzyl (3R)-6-(4-hydroxyphenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate (15 mg, 0.043 mmol) in toluene (5 mL) and methanol (1 mL). The reaction vessel is evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 18 h, the mixture was filtered and concentrated. MS 221 (M+1).

1. customThe reaction vessel is evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (1 atm)
4. filtrationthe mixture was filtered
5. concentrationconcentrated