Potassium Carbonate → HCID 68462157, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl-6-chloronicotinate (170 mg), 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (205 mg), potassium carbonate (150 mg) and dioxane (5 mL) was heated in a 100° C. oil bath overnight. An additional aliquote of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (100 mg) was added and heating was continued for five hours. The reaction was partitioned between water and EtOAc. The organics were washed with water, dried, and the solvent evaporated. The residue was purified by flash chromatography eluting with EtOAc to give methyl 6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)nicotinate as a white solid (180 mg), m/e=329 (M+1).

Provenance & Evidence