1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 87461411, compound

Participants

Reaction Steps

To a stirred solution of 2-(9-benzyl-1,3,4,9-tetrahydro-2H-b-carbolin-2-yl)pyrimidine-5-carboxylic acid (90 mg) in DCM (5 mL) was added EDCI (74 mg) at 0° C. and the reaction mixture was stirred for 20 min. NH2OTHP (30 mg) was added and the temperature was allowed to attain room temperature. After stirring at room temperature overnight, it was diluted with DCM. The organic layer was washed with water and then concentrated under vacuum. The residue obtained was purified by column chromatography to obtain N-(tetrahydro-2H-pyran-2-yloxy)-2-[9-benzyl-1,3,4,9-tetrahydro-2H-b-carbolin-2-yl]pyrimidine-5-carboxamide (60 mg, 53% yield), m/e=484 (M+1).

Provenance & Evidence