Hydrochloric Acid → HCID 68462226, compound

Participants

Reaction Steps

To a stirred solution of Example 8 (500 mg, mmol) in THF and water (10 mL, 1:1) was added lithium hydroxide (205 mg, mmol) at room temperature and the mixture was stirred for 4-5 hours. After completion, the reaction mixture was acidified using 1N hydrochloric acid. The mixture was extracted with EtOAc, washed with brine, the organics dried over sodium sulfate and concentrated to give 2-(1,3,4,9-tetrahydro-2H-b-carbolin-2-yl)pyrimidine-5-carboxylic acid (400 mg, 83% yield).

Provenance & Evidence