反应详情

1.33 ml of t-BuOH were dissolved in 50 ml of anhydrous CH2Cl2 and, at RT, 2.00 g of chlorosulfonyl isocyanate were added dropwise. During this, the internal temperature rose to 30° C. Stirring at RT for 1 hour was followed by dropwise addition of 1.96 ml of cyclopropylamine and leaving the reaction mixture to stand at RT for 16 hours. It was then washed 3 times with 15 ml of water each time. After drying over Na2SO4, the solvent was removed in vacuo. 1.3 g of an amorphous solid were obtained.

1. customrose to 30° C
2. customleaving the reaction mixture
3. waitto stand at RT for 16 hours
4. washIt was then washed 3 times with 15 ml of water each time
5. dry with materialAfter drying over Na2SO4
6. customthe solvent was removed in vacuo