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HRID501276

反应详情

EQUATION

反应方程式

HRID 501276 的结构方程式

REACTANTS

反应物

3
结构：CC1CCCCC1
HCID7962

Methylcyclohexane

C7H14

结构：C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12
HCID3034034

Quinine

C20H24N2O2

结构：COC(=O)[C@@H]1C[C@H]1C(=O)O
HCID12510972

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H]1C[C@@H]1C(=O)O
HCID11708069

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Add trans-cyclopropane-1,2-dicarboxylic acid monomethyl ester, Example 3a, (19.46 g) in acetone to quinine (43.8 g) In one portion. Heat the reaction to reflux, and then add methylcyclohexane (150 mL). After crystallization (5 times) from acetone/methylcyclohexane, collect 6.2 g of the diastereomeric salt (═D:+173, c:7.3 CHCl3)

WORKUP

后处理

  1. temperatureHeat
  2. customthe reaction
  3. temperatureto reflux
  4. customAfter crystallization (5 times) from acetone/methylcyclohexane
  5. customcollect 6.2 g of the diastereomeric salt (═D:+173, c:7.3 CHCl3)