HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → trans-2-(trans-2-Methylcyclohexylcarbamoyl)-cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Dioxane Methanol | HCID 21966525 | — |
| Reactant | trans-2-(4-Methyl-cyclohexylcarbamoyl)-cyclopropanecarboxylic acid methyl ester | HCID 68456814 | — |
| Product | trans-2-(trans-2-Methylcyclohexylcarbamoyl)-cyclopropanecarboxylic acid | HCID 68455212 | 87% |
Reaction Steps
Stir a solution of trans-2-(4-methyl-cyclohexylcarbamoyl)-cyclopropane-carboxylic acid monomethyl ester (Example 11a) (4.5 g, 19.8 mmol), 5N NaOH (40 mL) and MeOH/dioxane overnight. Concentrate the reaction mixture under vacuum, cool the resulting solution and acidify to pH 5. Collect the precipitate, wash (H2O) and dry under vacuum at 40° C. to obtain 3.7 g (87%) of solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772252B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-1255e7da9b914501b6bd5033fd21cb06 |
| Source note | uspto-grants-2010_08 |