HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 501341Generated: November 3, 2026
HCID 72434555, compound → HCID 58817532, compound
https://huagongshe.com/reaction/501341
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 72434555 | HCID 72434555 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1-Methoxyethanol | HCID 3015637 | — |
| Product | HCID 58817532 | HCID 58817532 | 104.7% |
Reaction Steps
4-{(3-Bromo-thiophen-2-yl)-[(2,2,2-trifluoro-ethyl)-hydrazono]-methyl}-piperidine-1-carboxylic acid tert-butyl ester (2.34 g, 4.98 mmol) was mixed with CuI (50 mg), CsCO3 (1.9 g, 1.2 eq) in methoxyethanol (25 mL). The mixture was heated to 75° C. for 1 hour. The mixture was then diluted with EtOAc and filtered. The filtrate was evaporated and the residue was purified via chromatography (eluted with 0-10% MeOH in DCM) yielding 2.03 g (>95%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07772252B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-47f268229fd54b759c928b16366852b3 |
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| Source note | uspto-grants-2010_08 |
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