524959-64-6 → HCID 11847990, compound

HRID 501354Notes

Reaction equation

HRID 501354 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]#[N:15].[H][H]>[Co].CO>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][NH2:15]

Participants

5

Reactant 2

HCID 11849170524959-64-6HCID 178418361HCID 178418361, compound

Product 1

HCID 11847990HCID 11847990, compoundYield 101.4%

Reagents, catalysts & solvents 2

HCID 104730CobaltCatalystHCID 887MethanolSolvent

Procedure

6.00 g (30 mmol) of (5-Methyl-2-phenyl-oxazol-4-yl)-acetonitrile were hydrogenated in the presence of 0.60 g of wet Raney Cobalt catalyst (Grace Davison Catalysts, Worms, Germany, Type Nr. 2700) in 54 mL of methanol in a 185 mL stainless steel autoclave under 9 bar of hydrogen pressure at 80° C. for 4 h. Removal of the catalyst by filtration, evaporation of the solvents and drying (45° C./10 mbar/2 h) afforded 6.15 g of 2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamine with a purity of 87.7% (HPLC area %).

Workup

  1. customRemoval of the catalyst
  2. filtrationby filtration, evaporation of the solvents
  3. customdrying (45° C./10 mbar/2 h)

Sources & evidence

ORD record
ord-4007a90f38124feda154c7db14c5fd08
Source dataset
uspto-grants-2010_08
Patent number
US07772264B2

Reaction notes

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