524959-64-6 → HCID 11847990, compound

HRID 501355Notes

Reaction equation

HRID 501355 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]#[N:15].[H][H]>[Co].C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][NH2:15]

Participants

5

Reactant 2

HCID 11849170524959-64-6HCID 178418361HCID 178418361, compound

Product 1

HCID 11847990HCID 11847990, compoundYield 125.8%

Reagents, catalysts & solvents 2

HCID 104730CobaltCatalystHCID 702EthanolSolvent

Procedure

6.00 g (30 mmol) of (5-Methyl-2-phenyl-oxazol-4-yl)-acetonitrile were hydrogenated in the presence of 0.60 g of wet Raney Cobalt catalyst (Blackwell-Catalloy, Type Nr. 1708042) in 54 mL of ethanol in a 185 mL stainless steel autoclave under 9 bar of hydrogen pressure at 70° C. for 3 h. Removal of the catalyst by filtration, evaporation of the solvents and work-up as in example 1 afforded 7.63 g of 2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamine as its mesylate salt with a purity of 100% (HPLC area %).

Workup

  1. customRemoval of the catalyst
  2. filtrationby filtration, evaporation of the solvents

Sources & evidence

ORD record
ord-60ec55fecbf04784b673f99dd11ceebc
Source dataset
uspto-grants-2010_08
Patent number
US07772264B2

Reaction notes

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