反应详情

温度

80 °C

trans-5-Methoxymethyl-3-tosyl-Cbz-pyrrolidine (3.55 g, 8.8 mmol) was dissolved in DMSO (8.8 mL). Finely ground NaCN(0.65 g, 13.2 mmol) was added, and the resulting reaction mixture was stirred 4 h at 80° C. The solution was cooled to room temperature, diluted with H20 (9 mL) and brine (9 mL), and extracted with ethyl acetate. The organic extracts were dried over MgSO4 and concentrated. The crude product was purified by column chromatography eluting with hexanes/ethyl acetate (2/1, v/v) to afford 2.09 g (87% yield) of the desired product as an oil.

1. customthe resulting reaction mixture
2. temperatureThe solution was cooled to room temperature
3. extractionextracted with ethyl acetate
4. dry with materialThe organic extracts were dried over MgSO4
5. concentrationconcentrated
6. customThe crude product was purified by column chromatography
7. washeluting with hexanes/ethyl acetate (2/1