Dimethylformamide → HCID 15332397, compound

Participants

Reaction Conditions

Reaction Steps

9.54 g of 7-benzylxanthine was dissolved in 250 ml of N,N-dimethylformamide, and 17 g of potassium carbonate and 14.2 ml of chloromethyl pivalate were added thereto. The mixture was stirred at 50° C. overnight. The reaction mixture was diluted with ethyl acetate, and washed with water and 1N hydrochloric acid. The organic layer was dried over anhydrous magnesium sulfate, then filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography. Thus, 12.8 g of the title compound was obtained from the fraction eluted with hexane-ethyl acetate (3:2).

Provenance & Evidence