Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 23070735, compound

HRID 501392Notes

Reaction equation

HRID 501392 reaction equation
F[B-](F)(F)F.[CH3:6][O+](C)C.[CH2:10]([N:14]1[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:17]([C:24](=[S:26])[NH2:25])[N:16]=[C:15]1[N:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:29][CH2:28]1)[C:11]#[C:12][CH3:13]>ClCCl>[CH2:10]([N:14]1[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:17]([C:24]([S:26][CH3:6])=[NH:25])[N:16]=[C:15]1[N:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][C:36]([CH3:38])([CH3:37])[CH3:39])=[O:34])[CH2:29][CH2:28]1)[C:11]#[C:12][CH3:13]

Participants

4

Reactant 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 23070778HCID 23070778, compound

Product 1

HCID 23070735HCID 23070735, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

0.235 of trimethyl oxonium tetrafluoroborate was added to a 20-ml dichloromethane solution of 0.58 g of t-butyl 4-[1-(2-butynyl)-5-ethoxycarbonyl-4-thiocarbamoyl-1H-imidazol-2-yl]piperazine-1-carboxylate, and the mixture was stirred at room temperature for 18 hours. 50 ml of dichloromethane was added to the solution, and the mixture was washed with 20 ml of a saturated sodium bicarbonate solution. The mixture was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 0.55 g of the title compound.

Workup

  1. washthe mixture was washed with 20 ml of a saturated sodium bicarbonate solution
  2. dry with materialThe mixture was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c6abed797b2b4dce8d95b8b181983354
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

Loading…