4-Methylpiperidine-1-carbonyl Chloride → HCID 86624821, compound

HRID 501482Notes

Reaction equation

HRID 501482 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([OH:11])[C:5]2=[C:4]([CH3:12])[CH:3]=1.[CH3:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](Cl)=[O:21])[CH2:16][CH2:15]1>>[CH3:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:11][C:10]2[C:5]3[C:6](=[N:7][C:2]([Cl:1])=[CH:3][C:4]=3[CH3:12])[N:8]([C:20]([N:17]3[CH2:18][CH2:19][CH:14]([CH3:13])[CH2:15][CH2:16]3)=[O:21])[N:9]=2)=[O:21])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 152215164-Methylpiperidine-1-carbonyl ChlorideHCID 178426134HCID 178426134, compound

Product 1

HCID 86624821HCID 86624821, compound

Procedure

In analogy to example 1, 1.2 g (6.54 mmol) of 6-chloro-4-methyl-1H-pyrazolo-[3,4-b]pyridin-3-ol were reacted with 1.29 g (7.98 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 238 mg (8%), M+H+: 434.27.

Sources & evidence

ORD record
ord-dc9407779d174e3596f1341631f805d8
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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