Zincchloride → HCID 86603140, compound

HRID 501503Notes

Reaction equation

HRID 501503 reaction equation
[CH3:1][CH2:2][C@@H:3]([C:5]([O:7][C@@H:8]1[C@@H:13]2[C@@H:14]([CH2:19][CH2:20][C@@H:21]([OH:29])[CH2:22][C@@H:23]([OH:28])[CH2:24][C:25]([O-:27])=[O:26])[C@@H:15]([CH3:18])[CH:16]=[CH:17][C:12]2=[CH:11][C@@H:10]([OH:30])[CH2:9]1)=[O:6])[CH3:4].[Na+].[Cl-].[Zn+2:33].[Cl-]>O>[CH3:1][CH2:2][C@@H:3]([C:5]([O:7][C@@H:8]1[C@@H:13]2[C@@H:14]([CH2:19][CH2:20][C@@H:21]([OH:29])[CH2:22][C@@H:23]([OH:28])[CH2:24][C:25]([OH:27])=[O:26])[C@@H:15]([CH3:18])[CH:16]=[CH:17][C:12]2=[CH:11][C@@H:10]([OH:30])[CH2:9]1)=[O:6])[CH3:4].[Zn:33]

Participants

4

Reactant 2

HCID 3007855ZincchlorideHCID 16759173Pravastatin sodium

Product 1

HCID 86603140HCID 86603140, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2 equivalents of pravastatin sodium dissolved in de-ionized water are reacted with a solution having 1 equivalent of zinc chloride in de-ionized water. Precipitation of crystalline pravastatin zinc occurs immediately at room temperature. The resultant salt was a 2:1 pravastatin to zinc salt. The preparation and characterization of pravastatin zinc are described more completely in Example 7 of US Application No. 20060034815.

Workup

  1. customare reacted with a solution
  2. customPrecipitation of crystalline pravastatin zinc
  3. customoccurs immediately at room temperature
  4. customThe preparation and characterization of pravastatin zinc

Sources & evidence

ORD record
ord-e0e3a528d94a4432b9abf9f9cad8a96d
Source dataset
uspto-grants-2010_08
Patent number
US07772277B2

Reaction notes

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