Hydrochloric Acid → 4-Amino-5,6,7,8-tetrahydronaphthalene-1-carbonitrile, hydrochloride salt

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Reaction Steps

A suspension of 2C (0.40 g, 1.87 mmol) in a mixed solvent of EtOH (2 mL) and conc. HCl (2 mL) was refluxed for 2 h. The resulting solution was allowed to cool to rt and concentrated under reduced pressure. The obtained solid was evaporated with toluene (2×) to yield compound 2D (0.25 g) as a solid.

Provenance & Evidence