1-Chloro-2,5-dimethyl-3-nitrobenzene → 3-Chloro-2,5-dimethylaniline

HRID 501558Notes

Reaction equation

HRID 501558 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[CH3:12].NC1C=CC(C#N)=C2C=1C=CC(C)(C)O2>>[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[NH2:9]

Participants

3

Reactant 2

HCID 190729401-Chloro-2,5-dimethyl-3-nitrobenzeneHCID 597542965-Amino-2,2-dimethyl-2H-chromene-8-carbonitrile

Product 1

HCID 203754823-Chloro-2,5-dimethylanilineYield 94.2%

Procedure

The title compound (1.70 g) was prepared from 21A (2.15 g, 11.6 mmol) in a manner similar to that described in Experiment 6C.

Sources & evidence

ORD record
ord-3d684ce32c8346ac9ef5bfe8f0556620
Source dataset
uspto-grants-2010_08
Patent number
US07772267B2

Reaction notes

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