HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(3-fluoro-2-methylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Fluoro-2-methylaniline | HCID 285553 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(3-fluoro-2-methylphenyl)acetamide | HCID 1489284 | 99.9% |
Reaction Steps
To a solution of 3-fluoro-2-methylaniline (2.65 g, 21.2 mmol) in EtOH (25 mL) at 0° C. was added acetic anhydride (2.60 g, 25.5 mmol). The mixture was stirred at rt overnight then concentrated under reduced pressure to give the title compound (3.54 g). LCMS: m/z 168[M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772267B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-bf3334cd362b4b6bb79702f5c40e07d9 |
| Source note | uspto-grants-2010_08 |