Hydrochloric Acid → HCID 59423758, compound

Participants

Reaction Steps

Step A (3): A solution of LiOH/H2O (2 M, 1.2 mL) was added to (S)-methyl 2-(N-methyl-2-propylpentanamido)pent-4-enoate (230 mg, 0.85 mmol) from Step A (2) in THF (4.0 mL) at rt. The reaction was stirred for 3 days. The mixture was poured into 1N HCl and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over NaSO4, and concentrated in vacuo to give 206 mg (95% yield) of the title compound as a white solid. LC-MS (M+H)+=256.23. 1H NMR (300 MHz, CDCl3) δ 0.78-0.92 (m, 6H) 1.11-1.44 (m, 7H) 1.50-1.69 (m, 2H) 2.47-2.83 (m, 3H) 2.97 (s, 3H) 4.98-5.16 (m, 3H) 5.59-5.78 (m, 1H).

Provenance & Evidence