HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-methyl 2-(3-ethoxy-N-methylthiophene-2-carboxamido)pent-4-enoate → (s)-2-(3-Ethoxy-n-methylthiophene-2-carboxamido)pent-4-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-methyl 2-(3-ethoxy-N-methylthiophene-2-carboxamido)pent-4-enoate | HCID 68466211 | — |
| Reactant | (S)-methyl 2-(3,3,3-trifluoro-N-methylpropylsulfonamido)hex-5-enoate | HCID 86622317 | — |
| Product | (s)-2-(3-Ethoxy-n-methylthiophene-2-carboxamido)pent-4-enoic acid | HCID 59423696 | 89% |
Reaction Steps
Step N (2): Same procedure as Step A (3). (S)-Methyl 2-(3,3,3-trifluoro-N-methylpropylsulfonamido)hex-5-enoate from Step N (1) was subjected to the ester hydrolysis protocol. The procedure provided 68 mg (89% yield) of the title compound as a colorless oil. LC-MS (M+H)+=284.27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772221B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-4bd6422535584fabae824eac88d5eac9 |
| Source note | uspto-grants-2010_08 |