HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-methylpropane → 6-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]4-(3-ethoxy-phenyl)-1-isobutyl-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | 6-[(6-Chloro-Pyridin-3-yl)-Hydroxy-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Ethoxy-Phenyl)-1H-Quinolin-2-One | HCID 22465397 | — |
| Product | 6-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]4-(3-ethoxy-phenyl)-1-isobutyl-1H-quinolin-2-one | HCID 22465400 | 42.9% |
Reaction Steps
The same procedure described in example 8, 6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethoxy-phenyl)-1H-quinolin-2-one (50 mg, 0.103 mmol) and 1-bromo-2-methylpropane (0.022 ml, 0.206 mmol) generated the title compound as a white solid (24 mg, 40% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710209B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3c71e74672144d9a8e9da2c41d24fa42 |
| Source note | uspto-grants-2004_03 |