HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 6-[(6-Chloro-Pyridin-3-yl)-Hydroxy-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-1-Cyclopropylmethyl-4-(3-Ethoxy-Phenyl)-1H-Quinolin-2-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 6-[(6-Chloro-Pyridin-3-yl)-Hydroxy-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Ethoxy-Phenyl)-1H-Quinolin-2-One | HCID 22465397 | — |
| Product | 6-[(6-Chloro-Pyridin-3-yl)-Hydroxy-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-1-Cyclopropylmethyl-4-(3-Ethoxy-Phenyl)-1H-Quinolin-2-One | HCID 22465413 | 7.2% |
Reaction Steps
The same procedure described in example 8, 6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethoxy-phenyl)-1H-quinolin-2-one (50 mg, 0.103 mmol) and (bromomethyl)cyclopropane (0.020 ml, 0.206 mmol) generated the title compound as a white solid (4 mg, 7% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710209B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-509f88a7079343d3b2e053c1355d64d3 |
| Source note | uspto-grants-2004_03 |