3-Hydroxybenzaldehyde → (1S,3R)-3-(Allyloxy)-6-propoxy-2,3-dihydro-1H-inden-1-amine

Participants

Role	Name	HCID	Charge
Reactant	3-Hydroxybenzaldehyde	HCID 101	—
Reactant	(S)-2,2,2-trifluoro-N-(6-methoxy-3-oxo-2,3-dihydro-1H-inden-1-yl)acetamide	HCID 1472787	—
Reactant	2,2,2-trifluoro-N-((1S,3R)-3-hydroxy-6-isopropoxy-2,3-dihydro-1H-inden-1-yl)acetamide	HCID 59423688	—
Product	(1S,3R)-3-(Allyloxy)-6-propoxy-2,3-dihydro-1H-inden-1-amine	HCID 59423826	—

Reaction Steps

Step AY (1). (1S,3R)-3-(Allyloxy)-6-propoxy-2,3-dihydro-1H-inden-1-amine was prepared from 3-hydroxybenzaldehyde using a series of procedures analogous to Steps AU (1-5), X (1) and U (2). 1H NMR (300 MHz, CDCl3) δ 0.9-1.0 (t, 3H) 1.6-1.8 (m, 2H) 2.6-2.8 (m, 1H) 3.8-3.9 (t, 2H) 4.0-4.2 (m, 3H) 4.7-4.8 (t, 1H) 5.1-5.4 (m, 2H) 5.8-6.0 (m, 1H) 6.7-6.9 (m, 2H) 7.2-7.3 (d, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07772221B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-47cecca7295a4be7a5b7cec1a643a5ab
Source note	uspto-grants-2010_08