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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 501740Generated: October 26, 2026

2,2,2-trifluoro-N-((1S,3R)-3-hydroxy-6-isopropoxy-2,3-dihydro-1H-inden-1-yl)acetamide → 3-(Allyloxy)-6-phenoxy-2,3-dihydro-1H-inden-1-amine

https://huagongshe.com/reaction/501740

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2,2-trifluoro-N-((1S,3R)-3-hydroxy-6-isopropoxy-2,3-dihydro-1H-inden-1-yl)acetamideHCID 59423688—
Reactant(1S,3R)-3-(Allyloxy)-6-propoxy-2,3-dihydro-1H-inden-1-amineHCID 59423826—
Product3-(Allyloxy)-6-phenoxy-2,3-dihydro-1H-inden-1-amineHCID 59423743—

Reaction Steps

Step BB (1). 3-(Allyloxy)-6-phenoxy-2,3-dihydro-1H-inden-1-amine was prepared using a series of procedures analogous to Steps AU (1-5), X (1) and U (2). 1H NMR (300 MHz, CDCl3) δ 1.6-1.8 (m, 1H) 2.7-2.9 (m, 1H) 4.0-4.2 (m, 3H) 4.7-4.8 (t, 1H) 5.1-5.4 (m, 2H) 5.8-6.0 (m, 1H) 6.8-7.1 (m, 5H) 7.2-7.4 (m, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07772221B2
Source datasetuspto-grants-2010_08
ORD IDord-305b3c0772984a2ab4d076816c7948eb
Source noteuspto-grants-2010_08