HCID 59423764, compound → HCID 86622363, compound

Participants

Reaction Steps

Step BK (1): 2,2,2-Trifluoro-N-((1S,3R)-3-hydroxy-6-methyl-2,3-dihydro-1H-inden-1-yl)acetamide (from Preparation BJ) was O-allylated by a procedure analogous to Step X(1) to afford 0.96 g (58% yield) of N-((1S,3R)-3-(allyloxy)-6-methyl-2,3-dihydro-1H-inden-1-yl)-2,2,2-trifluoroacetamide. LC-MS (M+H)+=260.09; 1H NMR (500 MHz, CDCl3) δ ppm 7.31 (d, 1H) 7.25 (bs, 1H) 7.18 (d, 1H) 6.87 (bs, 1H) 5.93-5.88 (m, 1H) 5.40-5.21 (m, 3H) 4.81 (d, 1H) 4.08 (bs, 2H) 2.69-2.65 (m, 1H) 2.37 (s, 3H) 2.08 (d, 1H).

Provenance & Evidence